symptoms of metallic discoloration, early symptoms and signs of metallic discoloration
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Metallic discoloration symptoms
Typical symptoms: Pigment abnormality, determined by the content of melanin in the skin, often in exposed parts
Related symptoms: skin purpura
Clinical manifestations are divided into the following categories:
1. It usually takes more than 8g of silver to produce clinical manifestations of silver deposition. Early for Henoch-Schonlein purpura appearance, then gradually appear pigmentation, showing light blue to blue-gray, severe for gray-black. Diffuse in the whole skin, there are few folds, and it is easy to see in exposed parts such as face and hands, especially in conjunctiva, nail and gingiva.
2. The total amount of gold deposition is generally more than 4g. It is characterized by diffuse blue-gray or lavender calmness. Most of them are in exposed parts, especially around orbit, sclera, folds and oral mucosa without damage. Histopathology showed that there were round or oval black granules with different sizes around dermal vessels and in histiocytes.
3. Bismuth deposition often occurs several years after being treated with bismuth. Diffuse blue-gray calmness produces a gray-blue or black line at the edge of gingival mucosa, which is called "bismuth line". Face and hands are obvious, which can involve sclera and oral cavity.
4. Mercury deposition can be caused by mercury deposition when it is used as bleach and external anti-inflammatory agent. Local skin cyan-gray pigmentation. It is more common in the face and neck, especially in the wrinkles of eyelids and nose and lips. Histopathology showed that there were regular brown-black granules in the upper dermis, some of which were free and some of which were in macrophages.
5. Iron deposition is treated with iron salt solution for dermatitis or as hemostatic. Deep golden brown deposits of iron can be seen at the damaged epidermis. Histopathology showed that there were iron-containing pigmophilic cells in the upper dermis, and melanin in the basic cells also increased slightly.
Diagnosis can be made according to clinical manifestations, skin lesions and histopathological characteristics.