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Immune infertility symptoms
Typical symptoms: Normal semen will contain a large amount of prostaglandin E and a glycoprotein, which has immunosuppressive effect, while semen precipitation hormone also has anti-complement activity.
Immune infertility symptoms
Immune infertility can be divided into three categories: homologous immunity, local immunity and autoimmunity.
Homologous immunity refers to the man's sperm, seminal plasma as antigen, in the woman's body to produce antibodies, so that sperm agglutination or sperm loss of activity. Under normal circumstances, women do not produce immune response, and only about 15%-18% of infertile women have anti-immune infertile sperm antibodies. When women suffer from menstrual period or endometritis, endometrium is damaged or anal intercourse, sperm and its antigen substances are easy to enter the blood flow and stimulate women's immune response.
2. Local immunity
Local immunity means that some infertile women's cervical mucosa and endometrium contain lymphoid cells that produce immunoglobulins G and A, and cervical mucus contains antisperm immunoglobulins G, A and M.. Therefore, cervix and female reproductive tract have local immunity to sperm.
Autoimmunity means that male sperm, seminal plasma or female eggs, reproductive tract secretions, hormones, etc. overflow the reproductive tract and enter their surrounding tissues, causing their own immune response, producing corresponding antibody substances in the body, affecting sperm vitality or follicle maturation and ovulation. Some studies have confirmed that 5% ~ 9% of infertile men have antisperm antibodies, which may be caused by bilateral vas deferens obstruction or ligation, or severe reproductive tract infection in the past.
4. Diagnostic criteria of immune infertility
(1) The infertility period exceeds 3 years;
(2) Other causes except infertility;
(3) Reliable detection methods confirm the existence of anti-fertility antibodies in vivo;
(4) Antifertility immunity interferes with sperm-egg binding in vitro.
Among the above four criteria, the clinical diagnosis of immune infertility can be made if the first three criteria are met, and the clinical diagnosis can be affirmed if the four criteria are met at the same time.
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