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symptoms of green monkey disease, early symptoms and signs of green monkey disease

symptoms of green monkey disease, early symptoms and signs of green monkey disease

Symptoms of green monkey disease

Typical symptoms: fever, swollen lymph nodes, macula, headache, bleeding gums, blood in the urine, vaginal bleeding, diarrhea, papules, nausea and vomiting, syncope, fatigue

Related symptoms: coma, swollen lymph nodes, nausea and vomiting

1. Symptoms

The incubation period is 3-9 days, sudden onset

1. Flu-like symptoms:

Initially, there are general fatigue, chills, profuse sweating, severe headache, conjunctivitis, profuse vomiting, watery diarrhea, diffuse abdominal pain, myalgia, etc. There may be small red spots on the buccal mucosa, blisters on the soft palate, and enlarged tonsils.

Fever: Body temperature peaks in 3 to 4 days and can reach above 40°C. Acute fever usually lasts for 2 weeks, but can rise again after 12 to 14 days.

Lymph nodes throughout the body are swollen, which can seriously affect the liver, heart, pancreas, kidneys, hematopoietic organs, and central nervous system. There may be sore throat, cough, chest pain, and pulmonary edema in the early stage of the disease; proteinuria may occur in the early stage, and renal failure may occur in the late stage; the conjunctiva of the patient may be congested, and eyelid or conjunctivitis may occur.

2. Characteristic symptoms:

Skin rash: 5 to 7 days after the onset, scattered red follicular papules appear on the buttocks, trunk, and limbs, and 1 day later, the maculopapular rashes merge, and severely hemorrhagic diffuse erythema. The skin has no itching sensation, which usually disappears after 3 to 4 days, desquamation, severe desquamation of palms, soles, and extremities.

Bleeding: At the same time as the rash appears, the patient has a bleeding tendency, such as epistaxis, bleeding gums, blood in urine and vaginal bleeding. Within 1 to 2 days of onset, vomit and stool contain a lot of blood. In severe cases, death may occur due to shock, accompanied by diffuse intravascular coagulation. 

2. Diagnosis

It can be diagnosed based on epidemiology and clinical manifestations. In acute cases, the patient's blood and urine can be taken, and the virus particles can be observed under an electron microscope to make a diagnosis. For virus isolation, the above-mentioned disease material can be used to inoculate Vero cells, and the virus antigens in the cells can be detected by immunofluorescence technology after 3 days. The indirect immunofluorescence test not only detects antibodies early and high levels, but also can detect two types of antibodies, IgG and IgM. IgM antibodies can appear 7 days after the onset, and reach a peak soon, and can be used for early diagnosis of the disease. 

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