symptoms of duodenal carcinoid, early symptoms and signs of duodenal carcinoid
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Duodenal cancer symptoms
Late symptoms: Carcinoid syndrome appears, manifested by paroxysmal flushing and diarrhea on the face, neck, upper limbs and upper trunk. Severe diarrhea may include dehydration, malnutrition, asthma, edema, and right heart failure.
Related symptoms: black edema of stool
On the one hand, duodenal carcinoids have common manifestations of duodenal tumors, such as melena, anemia, weight loss, jaundice or duodenal obstruction; on the other hand, they secrete a variety of biologically active substances. , Such as 5-HT, vasodilator, histamine, prostaglandin, somatostatin, glucagon, gastrin, etc. When these biologically active substances enter the blood circulation, especially when carcinoid liver metastases, these biological activities Substances directly enter the systemic circulation, and carcinoid syndrome may occur, which is manifested as flushing and diarrhea of the skin on the face, neck, upper limbs and upper trunk. Severe diarrhea may include dehydration, malnutrition, asthma, edema, and right heart failure.
However, it should be noted that individual patients with villous tubular adenoma can also secrete serotonin, which increases 5-HIAA (5-Hyaroxyindoleacetic acid, 5-hydroxyindole acetic acid), resulting in midgut type. Carcinoid sign.
It is mainly based on comprehensive analysis of clinical manifestations, X-ray examination, urine 5-HIAA determination and histopathological examination to confirm the diagnosis.
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