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primary local cutaneous amyloidosis examination and diagnosis of primary local cutaneous amyloidosis

primary local cutaneous amyloidosis examination and diagnosis of primary local cutaneous amyloidosis


Common examination of primary localized cutaneous amyloidosis

Check nameInspection siteInspection departmentCheck function
Urine routineOthersDepartment of Urology and Health CareCommonly used in the urinary system...
Stool routineOthersDigestive anorectalRoutine inspection can...
There may be accelerated erythrocyte sedimentation rate and abnormal globulin such as alpha or gamma globulin increase. In Nomland test, 1.5% Congo red solution was injected into the skin of suspicious skin lesions. After 24 ~ 48 hours, only red remained in amyloid protein. The positive rate of this disease was 80% by skin microscope.

Histopathology: The deposits of macula and mossy cutaneous amyloidosis are confined to dermal papilla, which are hemispherical, conical or lumpy, with cracks between them and epidermis. HE staining showed eosinous red and homogeneous, with a small amount of blue-stained cell fragments. Hyperkeratosis of epidermis, irregular thickening of granular layer and spinous cell layer, and atrophy of epidermis above amyloid protein. Basal cells are liquefied and degenerated, especially in plaque type. Amyloid protein is deposited around the blood vessels of cutaneous heterochromic amyloidosis, and irregular hyperplasia of epidermis and lengthening of epidermal process can be seen. Amyloid deposition around hair follicles is sheath-like. The epidermis of nodular cutaneous amyloidosis shrinks and thinns, and the epidermal process disappears. Large subepidermal amyloid expands from dermis to subcutaneous. Vascular wall may be thickened by amyloid deposition, sweat glands and adipocytes may also be involved, and chronic inflammatory cells infiltrate in dermis. Stained with methyl violet or crystal violet, amyloid protein has metachromatic phenomenon and can be dyed into bright purplish red; Congo red staining showed green and birefringence by polarizing microscope. PAS staining showed amyloid protein resistant to amylase. Immunofluorescence examination showed the deposition of immunoglobulin around amyloid protein, which has been confirmed as antikeratin autoantibody (AK auto Ab). DACM staining showed disulfide bond bands, which also indicated that amyloid protein originated from keratin.

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treatment method of primary local skin amyloidosis, how to do with primary local skin amyloidosis, and medication for primary local skin amyloidosis



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