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  4. the etiology of non-adrenaline proliferative pseudohermaphroditism, and what are the causes of non-adrenaline proliferative pseudohermaphroditism

the etiology of non-adrenaline proliferative pseudohermaphroditism, and what are the causes of non-adrenaline proliferative pseudohermaphroditism

the etiology of non-adrenaline proliferative pseudohermaphroditism, and what are the causes of non-adrenaline proliferative pseudohermaphroditism

Etiology of non-adrenaline proliferative pseudohermaphroditism: Pregnant women who take progesterone, estrogen and androgen may make female embryos or fetuses masculine

First, the cause of the disease

Abnormal sexual differentiation caused by mother and exogenous androgen increase, Including the application of progesterone (19-demethyltestosterone derivatives, including progesterone, norethindrone, norethindrone, danazol, gestrinone, levonorethindrone and medroxyprogesterone) and androgen preparations with potential androgen activity in the first gestational season, which causes masculinity, while the application in the second gestational season only causes clitoral hypertrophy and urogenital sinus malformation. Maternal masculine tumors during pregnancy, including arrhenoblastomas, metastatic ovarian cancer (Kr ü kenberg tumors), luteomas, lipoid tumors, stromal cell tumors and interstitial cell hyperplasia, can also cause masculinity of female fetus.

Second, the pathogenesis

Taking sex hormones during pregnancy to promote masculinity is related to the following factors: such as the type and dose of sex hormones; The morning and evening of pregnancy; Placental permeability and its metabolism; Metabolism and degradation of exogenous sex hormones in pregnant women; As well as the sensitivity of fetal reproductive system tissues to sex hormones and metabolic dysfunction.

Progesterone taken in the treatment of threatened abortion is mostly synthetic preparation, and its biological action characteristics include not only the action of progesterone, but also the action of androgen. Moreover, the action of synthetic progesterone is more than 10 times stronger than that of natural progesterone, and its excretion is slow and its action time is longer, so it is easy to lead to masculinization of female fetus. Taking estrogen causes female fetus to be masculine because synthetic estrogen can make progesterone metabolism disorder and produce androgen, and synthetic estrogen can stimulate fetal adrenal cortex and promote its secretion of androgen.

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symptoms, early symptoms and signs of non-adrenergic pseudohermaphroditism



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