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how to diagnose and differentiate giant cell tumor of bone-giant cell tumor of bone is easy to confuse the disease

how to diagnose and differentiate giant cell tumor of bone-giant cell tumor of bone is easy to confuse the disease

Differentiation of giant cell tumor of bone

Giant cell repair granuloma is common in adolescents between 10 and 20 years old, and it tends to occur in the mandible. It is now believed that those who occur in the jaws are usually not true GCTs but giant cell repair granulomas. Microscopically, the multinucleated giant cells are small in size, medium in number, and unevenly distributed. They often gather at the sites of hemorrhage, necrosis, and hemosiderin deposits, and bone-like and bone tissue formation can be seen. The prognosis of the lesion is good after simple curettage.

1. Aneurysmal bone cyst

It mostly occurs in adolescents under the age of 20. Vertebrae and flat bones are common, but they can also occur in long backbones. X-ray is similar to GCT, showing eccentric expansion of bone and ablation of bone cortex. The difference from GCT microscope is that multinucleated giant cells are unevenly distributed and mostly located near vascular cysts and hemorrhages. The cell body is small and the interstitium is mature fibers. organization. Simple curettage of the lesion will recur in a quarter, and the effect of mass resection or curettage combined with bone grafting is better. Multinucleated giant cell bone lesions are very complex and can easily lead to misdiagnosis if they are not vigilant. For children, the lesions are on the vertebrae, jaws and hand and foot bones except the sacrum. The lesions are multiple and usually not GCT. It is particularly worth mentioning that the fracture can be misdiagnosed as GCT complicated with pathological fracture due to necrosis, hemorrhage and multinucleated giant cell reaction, which should be differentiated.

2. Solitary bone cyst

It usually occurs in the metaphysis before the unhealed epiphysis in adolescents, showing symmetrical expansion and less separation.

3. Chondroblastoma

It usually occurs in the epiphyses of long bones in people under the age of 20. There are often calcification points in the tumor, with fewer septals and clear edges.

4. Non-ossifying fibroma

It is more common in adolescents. It is more common in long tubular bones. It grows eccentrically and develops along the long axis with clear edges and hardened edges.

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